International Journal of Trend in Scientific Research and Development

Background The main pathophysiology of diabetes mellitus DM is oxidative stress, which is an imbalance between production of free radicals and antioxidant system in the body. Persistent hyperglycemia causes increased production of free radicals especially reactive oxygen species ROS , in tissues from glucose auto oxidation and protein glycosylation. Aim To investigate the comparative effect of Aloe vera gel, rind and a combination of gel and rind on the oxidative stress in alloxan induced diabetic rats. Materials and Methods 25 male wistar rats weighing between 220-260g were used for this study. They were divided into five groups A E of 5 rats each. Group A served as positive control group and received distilled water only. Group B was the negative diabetic group with no extract administration. Groups C, D and E were diabetic groups that received 300mg kg of Aloe vera rind, 300mg kg of Aloe vera gel and combination of 150mg kg of Aloe vera rind and 150 mg kg of Aloe vera gel respectively. Extract administration was done orally, once daily for 14 days. At the end of administration, oxidative stress biomarkers were assessed. Results There was significant decrease in SOD level in group B 9.87±0.20 when compared with the control 15.88±0.39 . Conversely, groups C 17.50±0.35 and D 17.94±0.22 showed significant increase when compared with the control. However, group E showed no significant change when compared with the control 15.88±0.39 . On the other hand, there was significant increase in SOD in control group A 15.88±0.39 and all the test groups when compared with group B 9.87±0.20 . Similarly, a significant increase in MDA was observed in group B 5.39±0.20 when compared with the control 4.15±0.21 . Groups C 3.62±0.20 and D 3.23±0.12 showed significant decrease when compared with control 4.15±0.21 . Furthermore, group E 4.14±0.26 showed no significant difference when compared with the control 4.15± 0.2 . On the other hand, groups A and all the test groups showed significant decrease in MDA when compared with group B 5.39±0.20 . Conclusion Aloe vera gel and Aloe vera rind extracts singly appeared more potent in reducing oxidative stress in diabetic rats when compared to combined extracts of Aloe vera rind gel at lower doses. 

by M. C. Igbokwe | V. U. Igbokwe | N. N. Njoku-Oji | C.O.J Okonkwo "Comparative Effect of Aqueous Aloe Vera Extracts on Oxidative Stress in Alloxan-Induced Diabetic Wistar Rats" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd46381.pdf 

Paper URL : https://www.ijtsrd.com/humanities-and-the-arts/philosophy/46381/comparative-effect-of-aqueous-aloe-vera-extracts-on-oxidative-stress-in-alloxaninduced-diabetic-wistar-rats/m-c-igbokwe

callforpapercommerce, ugcapprovedjournalsincommerce, commercejournal

The article examines the philosophical views and teachings of Central Asian thinkers on the formation of the ecological culture of the individual. Islamic teachings also pay special attention to the ontological problems of the ecological worldview, ie the question of the origin of nature. The article provides an in depth analysis of important scientific data that enrich the individuals ecological outlook. The author provides an opportunity to scientifically study the ecological culture of the individual and the role of religious values in it. 

by Kilichov Feruzbek "The Teachings of Central Asian Thinkers on the Formation of Personal Ecological Culture" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd41165.pdf 

Paper URL: https://www.ijtsrd.comhumanities-and-the-arts/philosophy/41165/the-teachings-of-central-asian-thinkers-on-the-formation-of-personal-ecological-culture/kilichov-feruzbek

callforpaperpharmacy, pharmacyjournal, internationalpeerreviewedjournal

The article examines the emergence of the science of sociolinguistics, role in the area of linguistics. About the researchers who contributed to the development of science and their scientific activities. 

by Rayhona Numonovna Nuritdinova "The Formation of Sociolinguistics as a Science and a Place in Linguistics" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | International Research Development and Scientific Excellence in Academic Life , March 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38754.pdf 

Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/philosophy/38754/the-formation-of-sociolinguistics-as-a-science-and-a-place-in-linguistics/rayhona-numonovna-nuritdinova

internationaljournalsofcomputerscience, callforpapercomputerscience, ugcapprovedjournalsforcomputerscience 

In this article, the formation of an ecological worldview in the world is not only a deterrent to global problems, but also means for environmental security, the solution of which takes place with the participation of human consciousness, reflection, intellect, intellectual potential and whole values and its ontological, epistemological, philosophical aspects within the Aral Sea region are analyzed. 

by Jumaniyaz Ramatov | Rozigul Umarova "Constructive and Optimal Solutions for the Formation of a Stable Ecological Situation in the Aral Sea Region of Uzbekistan" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | International Research Development and Scientific Excellence in Academic Life , March 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38753.pdf 

Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/philosophy/38753/constructive-and-optimal-solutions-for-the-formation-of-a-stable-ecological-situation-in-the-aral-sea-region-of-uzbekistan/jumaniyaz-ramatov

internationaljournalsofcomputerscience, callforpapercomputerscience, ugcapprovedjournalsforcomputerscience 

This article analyzes the socio political movements of the Young Khiva people in the Khiva Khanate in the early twentieth century.In particular, it is also mentioned about the fact that the revolution in Russia has a positive impact on the growth of movements towards democratic reforms in Turkestan.From the beginning of 1917 the movement for democratic reform was began in the Khiva khanate. The young Khiva people whoarmed with the idea of independence took an active part in this movement with the idea of changing the political situation in the khanate and implementing some democratic reforms. 

by Bakhtigul Abdupattaevna Mamadaminova "Some Considerations about the Socio-Political Movements of Young Khivans" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | Innovative Development of Modern Research , April 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd39941.pdf

Paper URL : https://www.ijtsrd.com/humanities-and-the-arts/philosophy/39941/some-considerations-about-the-sociopolitical-movements-of-young-khivans/bakhtigul-abdupattaevna-mamadaminova

openaccessjournalofengineering, engineeringjournal, paperpublicationforengineering

The recurrence of animal to man pathologies and its lethality has motivated our inquiry into a rethink of our relationship with fauna species. Mindful of the lethality of zoonoses, the duration to develop vaccines for the prevention of zoonoses, the inevitable interaction of fauna and humans, the fragile nature of the human immune system to fight zoonoses, this paper proposes a “zooimmunocament” which humanity needs to borrow the genetic and immunologic ingredients from the fauna species where they don’t develop a malady and used for his therapy. This therapy is far from vaccines. Humanity thanks to his evolutionary advancement in intelligence can control and make use of the fauna immune system for the fight against zoonotic zoonoses pathologies. Since those pathogens in fauna species do not cause harm, humanity can exploit the set up of their defense system for a possible therapy thus the appellation zooimmunocament. 

by Ezekiel Kikoh | Ngai Roland Yinkfu "Zoonoses-pandemics and the Urgency of a “Zooimmunocament”" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38457.pdf 

Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/philosophy/38457/zoonosespandemics-and-the-urgency-of-a-“zooimmunocament”/ezekiel-kikoh

peerreviewedinternationaljournal, paperpublicationforstudent

A new branch of ethics named Environmental Ethics’ has emerged recently, but a search of ancient Indian literature reveals that environmental awareness was widespread in ancient Indian human society and that people at the time thought about it. However, due to the low level of environmental pollution at that time no sm tisastrakaras has expressed any thought about the environment like the thinkers in the modern environment, but it cannot be said that ancient India was not aware of the protection of the natural environment at all because ancient India thought of environment in its own way. The name of Yajñavalkya Sa hita is especially significant as Sm tishastra. Like Manu, Yajñavalkya is also known as a philosopher and spiritual guru. Although the various social and state provisions are the subjects of discussion in the Yajñavalkya Sa hita. The statements he makes about the environment in the context of the various social issues are not insignificant. In this article, I want to draw the attention about the reflection of all these thoughts in Maharshis discussion. 

by Kousik De "Environmental Awareness Reflected in the Yājñavalkya Saṁhitā" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38469.pdf 

Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/philosophy/38469/environmental-awareness-reflected-in-the- Yājñavalkya Saṁhitā/kousik-de

ugclistedjournals, paperpublication

 This paper examines the clear cut separation and distinction of the role and business of the church and the state. Social disorder, wars and conflicts of diverse natures have always resulted from the inefficient link between the church and the state. My focus in this paper is to justify that, without the establishment of a real boundary between the church and the state, there can be no certain end to the controversies that will be always arising. This principle of separation is geared toward the secularization of politics, as a means of putting the different sectors of the society in their right positions, by emphasizing on the fact that, the affairs of heaven do not have any business with those of the earth and restricting the temptation of power abuse by either the church or the state or both. I emphatically portray that, the church must be separated from the state exactly and absolutely because it is considered as the first method to resolve the different problems related to the misuse of power that usually occur within the society. I further admit that, the church is mainly concerned about the interests of men’s souls which involve exercising purity, God worship, living a holy and decent life, aimed at acquiring the salvation of individual souls. Finally, I conclude that, the aspiration of the state is outward, external or public and centered on the commonwealth, geared toward the procuring, preserving and advancing of civil interests which include life, liberty, indolence of the body, and the possession of outward things, such as money, land, houses, furniture. 

by Nde Paul Ade "The Church and the State: A Critical Reading of John Locke’s Theologico-Political Thought" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd38332.pdf

Paper URL : https://www.ijtsrd.com/humanities-and-the-arts/philosophy/38332/the-church-and-the-state-a-critical-reading-of-john-locke’s-theologicopolitical-thought/nde-paul-ade

internationaljournalofscience, openaccessjournalofscience, ugcapprovedjournalsforscience 

by Bengyedla Ferdinant Nteh "Nature and Human Domination" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd33486.pdf

Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/philosophy/33486/nature-and-human-domination/bengyedla-ferdinant-nteh

ugcjournallist, listofugcapprovedjournals, researchpublication

by Djurayev Avaz Akhmedjanovich | Khidirov Kholmurod Norimovich "Philosophical Analysis of the Aspects of Genius and Talent" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd33114.pdf 

Paper Url :https://www.ijtsrd.com/humanities-and-the-arts/philosophy/33114/philosophical-analysis-of-the-aspects-of-genius-and-talent/djurayev-avaz-akhmedjanovich

internationaljournalsinengineering, callforpaperengineering, ugcapprovedengineeringjournal 

A critical analysis of Quine metaphysics leads to the idea that nothing exist independent of natural sciences. This obliges us into the question can metaphysics be reduced to a natural science To tackle this question Quine dismantles First Philosophy by considering it as prior philosophy which is meaningless in the context of natural sciences. Affirmatively, he adopts naturalism whose locus is science. In line with this, he revived metaphysics from its speculative or abstract nature to a discipline that is continuous with natural sciences. This is attained through the pragmatic value of metaphysics. That is, via its application in the scientific processes. But in the final analysis metaphysics cannot be accommodated by natural sciences because it would be the loss of its essence of speculation and abstraction. The abortive revival of metaphysics is also explained by the fact natural sciences have a common denominator which is the scientific method and metaphysics is not structure on this method.

by Abdu Karimo Baji | Chatue Jacques "Quine and the Abortive Scientific Revival of Metaphysics" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd32923.pdf 

Paper Url :https://www.ijtsrd.com/humanities-and-the-arts/philosophy/32923/quine-and-the-abortive-scientific-revival-of-metaphysics/abdu-karimo-baji

internationaljournalsofcomputerscience, callforpapercomputerscience, ugcapprovedjournalsforcomputerscience 

by Matluba Sadullaeva Akhrorovna "Philosophy of Numerical Symbolism in World’s Cultures" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd33219.pdf 

Paper Url :https://www.ijtsrd.com/humanities-and-the-arts/philosophy/33219/philosophy-of-numerical-symbolism-in-world’s-cultures/matluba-sadullaeva-akhrorovna

callforpaperlanguages, languagesjournal, bestjournal