International Journal of Trend in Scientific Research and Development

at nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide HCl were prepared using HPMC E5, E15 polymers as film forming agents and polyethylene glycol 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action. 

BY Indrajeet. B. Pawar | Prashant. H. Khade | Sujit. S. Kakade "Illustrative Review on Needle Free Injection Technology" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, 

URL: https://www.ijtsrd.com/papers/ijtsrd29615.pdf  

Paper URL: https://www.ijtsrd.com/pharmacy/novel-drug-delivery-sys/29615/illustrative-review-on-needle-free-injection-technology/indrajeet-b-pawar

paper publication in science, call for paper medical science, ugc approved management journal

The buccal region of the oral cavity is an attractive target for administration of the drug of choice, particularly in overcoming deficiencies associated with the latter mode of administration. Problems such as high first pass metabolism and drug degradation in the gastrointestinal environment can be circumvented by administering the drug via the buccal route. Moreover, rapid onset of action can be achieved relative to the oral route and the formulation can be removed if therapy is required to be discontinued. It is also possible to administer drugs to patients who unconscious and less co operative. To prevent accidental swallowing of drugs adhesive mucosal dosage forms were suggested for oral delivery, which included adhesive tablets, adhesive gels, adhesive patches and many other dosage forms with various combinations of polymers, absorption enhancers. Natural polymers have recently gained importance in pharmaceutical field. Mucoadhesive polymers are used to improve drug delivery by enhancing the dosage form's contact time and residence time with the mucous membranes. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. When the biological substrate is attached to a mucosal layer then this phenomenon is known as mucoadhesion. The substrate possessing bioadhesive polymer can help in drug delivery for a prolonged period of time at a specific delivery site. The studies of Mucoadhesive polymers provide a good approach of mucoadhesion and some factors which have the ability to affect the mucoadhesive properties of a polymer. Both natural and synthetic polymers are used for the preparation of mucoadhesive buccal patches. In addition to this, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity. 

In the body, there is a system which is responsible for the specific resistance and in some aspects; non specific resistance is the lymphatic system which maintains homeostatic balance. This system closely allied with all the systems. Lymphatic system consist fluid called, lymph. It assists in circulating body fluids and helps in defend the body against disease causing agents. 

B cells, T cells and antibodies protect all body systems from attack by harmful foreign invaders (pathogens), foreign cells, and cancer cells. Major functions of lymphatic system are draining excess interstitial fluid, transport dietary lipids and carring out immune responses. Now a days there is a high risk to immune system because of the diseases or due to disorders. 

In recent innovations, nano technology plays a major role and there are the different drug carriers are used to avoid the major damage to immune system. This review explains about the drug carriers to target lymphatic system to release the drug at a specific part in the lymphatic organs, tissue or lymph in different disease conditions. 

by Kousar Begum | Dr. B. Chandra Sekhara Rao | Nukala Umasri "Novel Drug Carriers to Target Lymphatic System - A Review" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-3 , April 2018,