International Journal of Trend in Scientific Research and Development

Solubility are often defined because the amount of solute dissolved during a solvent at certain conditions to yield a single ¬phase system. Solubility of active pharmaceutical ingredients is taken into account the foremost parameter to urge the most desired drug concentration generally circulation so as to realize the specified therapeutic effect. Poor aqueous solubility considered the most problem occurs within the formulation progress of latest chemical entities additionally to the quality improvement solubility is that the main dispute for formulation scientists. The drug must appear as solution at the location of absorption so as to be absorbed. Many physical or chemical modification techniques are wont to improve the solubility of low aqueous soluble drugs, in addition to other techniques like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant and complexation. The selection of the solubility improvement methods depends on drug characteristics, location of absorption and therefore the features of the administered dosage form. 

by Utkarsha R. Gavhane | Trusha P. Shangrapawar | Ashok Bhosale "A Review: Solubility Enhancement and its Technique" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd42415.pdf 

Paper URL: https://www.ijtsrd.compharmacy/pharmaceutics/42415/a-review-solubility-enhancement-and-its-technique/utkarsha-r-gavhane

callforpaperarts, artsjournal, peerreviewedjournal 

A Microsponge Delivery System MDS is patented, highly cross linked, porous, polymeric microspheres that can entrap wide range of actives and then release them onto the skin over a time and in response to trigger. It is a unique technology for the controlled release of topical agents and consists of microporous beads, typically 10 25 microns in diameter, loaded with active agent. In this study, Ketoconazole microsponges were prepared by using quasi emulsion solvent diffusion method. The microsponges thus prepared, were evaluated for production yield, loading efficiency, particle size analysis, in vitro release study of microsponges, and stability. Hence, the present work concluded that MDS has a great potential in topical delivery of drugs like Ketoconazole, with added advantage of reduction in irritation profile due to the controlled release and possible enhancement in the activity due to amorphization of the drug. 

by Vilas S. Bhagat | Sanjay R. Arote "Formulation Development and In-Vitro Evaluation of Microsponge Drug Delivery System of Antifungal Drug" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3 , April 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd39870.pdf 

Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/39870/formulation-development-and-invitro-evaluation-of-microsponge-drug-delivery-system-of-antifungal-drug/vilas-s-bhagat

callforpaperbiologicalscience, biologicalsciencejournal

Objective Nanostructured lipid carrier NLC based topical gel of Piroxicam PXM was formulated with the aim of controlled release action and to reduce systemic side effect for the treatment of an arthritic condition. Methods NLCs developed using high pressure homogenization method and optimized using a 32 factorial design with response surface methodology using design expert software. NLCs were characterized for particle size, zeta potential analysis, drug entrapment efficiency, and in vitro drug release studies to select the optimized formulation. The NLCs were suitably gelled and evaluated with respect to homogeneity, pH, viscosity, gel strength, spread ability, rheological characteristics, drug content, in vitro diffusion, and stability study. Safety of the NLC based gel was assessed using primary skin irritation studies, and efficacy was confirmed using carrageen an induced rat paw edema model. Results NLCs formulation comprising 2 of lipid 60 40 and surfactant 1.50 was confirmed as an optimized batch having a particle size 138.2±3.60 nm with polydispersibility index value 0.344±0.034. The zeta potential value indicates good physical stability. Based on the results from the in vitro release study it was shown that the formed gels had the ability to extend release of PXM for 24 h and showing percentage drug release of 90.92 ±1.96 at the end of 24 h. Skin irritation studies revealed that the optimized gel formulation shows no erythema, edema, or ulceration. Conclusion The overall results of the present study clearly indicated promising potentials of NLC based gel for delivering PXM topically over the conventional gel. 

by Dr. G. Jagadish | Dr. Rita Mourya | Dr. Amith Nayak "Piroxicam Nanostructured Lipid Carrier Drug Delivery System" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3 , April 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd39912.pdf 

Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/39912/piroxicam-nanostructured-lipid-carrier-drug-delivery-system/dr-g-jagadish

internationaljournalsinengineering, callforpaperengineering, ugcapprovedengineeringjournal 

Deaths that are caused due to coronary heart disease CHD is a major cause of deaths in most of the population. Even though the mortality rate has been reducing, dyslipidemia is the major known risk factor in pathogenesis of CHD. In this paper we review the role of dyslipidemia and lipid changes that occur in men and women at different stages. We discuss about dyslipidemia causes symptoms and treatments and all the other issues that arise due to dyslipidemia. We talk about different drugs that are used in treating dyslipidemia and their side effects. 

by Yong Yuan | Wen Chen | Lei Luo | Chen Xu "Dyslipidemia: Causes, Symptoms and Treatment" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38594.pdf 

Paper Url: https://www.ijtsrd.com/pharmacy/pharmaceutics/38594/dyslipidemia-causes-symptoms-and-treatment/yong-yuan

callforpapermedicalscience, medicalsciencejournal

Size reduction is one of most fundamental unit operation which is of prime importance in pharmacy. It helps in improving stability and bioavailability, reducing toxicity, enhancing release and providing better formulation opportunities for drug. In the recent trends, the drugs in nanometer size range have found to increase the performance in variety of dosage forms. The word 'nano’ is a Latin word, which means'dwarf’. Nano size refers to 10 9 of a particular unit thus nanometer is 10 9 of a meter. Nanotechnology is the science that deals with the processes that occurs at molecular level and of nanolength scale size. Nanotechnology has shown tremendous progress in many fields but in pharmaceutical fields are yet to be explored, although, it has powerful impact in various medical fields such as biophysics, molecular biology, bioengineering, cardiology, oncology, ophthalmology, endocrinology immunology etc. Nanotechnology provides intelligent system, devices and materials for better pharmaceutical applications. The current status of nanotechnology in pharmaceutical field includes development of Nano medicine, tissue engineering, nano robots, biosensors, biomarkers etc. Pharmaceutical Nanotechnology provides opportunities to improve materials, medical devices and help to develop new technology where existing and more conventional technologies may be reaching their limits. Thus in the coming years advancements in this field will led to the improved form of drug delivery as well as other prospects of medicine and pharmacy.

by Mr. Rajesh Dumpala | Mr. Chirag Patil "Current Trends of “Nanotechnology” in Pharmaceutical" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38414.pdf 

Paper Url: https://www.ijtsrd.com/pharmacy/pharmaceutics/38414/current-trends-of-“nanotechnology”-in-pharmaceutical/mr-rajesh-dumpala

callforpaperchemistry, chemistryjournal, openaccessjournalofchemistry 

 Background The concept of targeted drug delivery is meant for attempting to concentrate the drug within the tissues of interest while reducing the relative concentration of the medication within the remaining tissues.Now each day the recent development in new drug delivery systems plays a significant role in pharmaceutical industries. As a result, drug is localized on the targeted site. Hence, surrounding tissues arent plagued by the drug. So, carrier technology offers an intelligent approach for drug delivery by coupling the drug to a carrier particle like microspheres, nanoparticles, liposomes, niosomes etc which modulates the discharge and absorption characteristics of the drug. Microspheres are characteristically free flowing powders consisting of proteins or synthetipolymers which are biodegradable in nature and ideally having a particle size but 200 µm. its the reliable means to deliver the drug to the target site with specificity, if modified, and to take care of the specified concentration at the location of interest without untoward effects.Microspheres received much attention not just for prolonged release, but also for targeting of anticancer drugs to the tumor. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues within the body.Microspheres are free flowing powder that comprises proteins or synthetic polymers that are biodegradable in nature ranging between 1 1000nmin size. A neat controlled drug delivery system can overcome a number of the issues of conventional therapy and enhance the therapeutic efficacy of a give drug. There are various approaches in delivering a therapeutic substance to the target site in a very sustained controlled release fashion. Among them microspheric drug delivery system has gained enormous attention because of its wide selection of application because it covers targeting the drug to particular site to imaging and helping the diagnostic features. the aim of the review is to compile various sorts of microspheres, different methods to preparation, its applications and also various parameters to guage their efficiency.Materials and methods there are differnt methods of preparation of microspheres 1. Bio adhesive microspheres2. Magnetic microspheres3. Floating microspheres4. Radioactive microspheres5. Polymeric microspheresi Biodegradable polymeric microspheresii Synthetic polymericResult from this review, we are able to prepared micropsheres by using differing kinds of method of preparation.Conclusion From this review, we could conclude that various sorts of preparation methods together with its pharmaceutical application are being employed for Microspheres as a drug delivery system for delivering the definite amount of medicines in a very controlled manner. its going to include oral, targeted, sustained, topical, naso pulmonary and various biotechnology applications like gene therapy etc. By developing newer delivery technologies, it can give way more therapeutic and commercial benefits by improving the security and reducing the toxicity. By this we can prepared t microspheres by using different method of preparation 

BY Sakshi Ghuge | Prof. Smita More "Microspheres and Kinds" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd35866.pdf

Paper URL : https://www.ijtsrd.com/pharmacy/pharmaceutics/35866/microspheres-and-kinds/sakshi-ghuge

callforpaperbiologicalscience, biologicalsciencejournal

Background Tablet is that the preferred among all dosage forms existing today thanks to its convenience of self administration, compactness and simple manufacturing however in many cases immediate onset of action is required than conventional therapy. There are novel kinds of dosage form.The scenario of pharmaceutical drug delivery are expeditiously challenging, but conventional pharmaceutical dosage forms are still dominating. Immediate release dosage forms are those wherein =85 of labeled amount dissolves within 30 min. Superd is integrants are accustomed improve the efficacy of solid dosage forms. orms that act very quickly after administration To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. There are novel forms of dosage forms that act very quickly after administration. the fundamental approach utilized in development tablets is that the use of superdisintegrants like Cross linked carboxymelhylcellulose Croscarmeliose , Sodium starch glycolate Primogel, Explotab , Polyvinylpyrrolidone Polyplasdone etc. which give instantaneous disintegration of tablet after administration. Immediate release liquid dosage forms and parenteral dosage form have also been introduced for treating patients. Dosage form can be suspensions with typical dispersion agents like hydroxypropylmethylcellulose, dioctylsulfosuccinate etc. a replacement dosage form allows a manufacturer to increasemarket exclusivity, while offering its patient population a more convenient dosage form or dosing regimen.These superdisintegrants provide instantaneous disintegration of the tablet after administration within the stomach. This article provide an exhaustive account illustrating the significances of superdisintegrant within the immediate release of tablets and therefore the mechanism of disintegration together with various conventional techniques and novel granulation technology wont to prepare immediate release tablets. ach. Thus, decreasing the disintegration time which successively enhances drug dissolution rate. Results From this review, we can ready to develop and evaluate immediate release tablets.also we must always understand role of immediate release tablets.Conclusion Most of the patients need quick therapeutic action of the drug, leading to poor compliance with conventional drug therapy which results in reduced overall therapy effectiveness. For this we will conclude that immediate release tablets are simpler. because immediate release tablet shows quick effect. 

BY Sakshi Ghuge | Prof. Smita More "Preparation and Evaluation of Immediate Release Tablets" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd35867.pdf

Paper URL : https://www.ijtsrd.com/pharmacy/pharmaceutics/35867/preparation-and-evaluation-of-immediate-release-tablets/sakshi-ghuge

callforpapermathematics, mathematicsjournal, ugcapprovedjournalsinmathemetics

Oral Osmotic Drug Delivery System is the new found delivery system of Novel Drug Delivery System. Oral Osmotic Drug Delivery System works on the principle of Osmosis and Osmotic Pressure for the pre planned and correct delivery of the drugs into the biological systems. Being independent of the pH and physiological conditions, it provides an upper hand into delivery of drugs of various biological diversity. In this article a detailed discussion of Oral Osmotic Drug Delivery System its components, classification, formulation aspects, evaluation techniques are described. 

by Kanchan A. Lodhe | Vikram N. Sancheti "Review on Osmotically Controlled Drug Delivery System" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd38144.pdf

Paper URL : https://www.ijtsrd.com/pharmacy/pharmaceutics/38144/review-on-osmotically-controlled-drug-delivery-system/kanchan-a-lodhe

openaccessjournalofengineering, engineeringjournal, paperpublicationforengineering

by Mr. Rajesh Dumpala | Mr. Chirag Patil "A Review on Solid Oral Dosage Forms with an Industrial Perspective for Process Validation" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd33624.pdf

Paper Url: https://www.ijtsrd.com/pharmacy/pharmaceutics/33624/a-review-on-solid-oral-dosage-forms-with-an-industrial-perspective-for-process-validation/mr-rajesh-dumpala

internationaljournalofscience, openaccessjournalofscience, ugcapprovedjournalsforscience 

by Lokhande Jyoti | More Smita "Tablet Coating: Not Only a Technical Work but also a Creative Art" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd33357.pdf

Paper Url: https://www.ijtsrd.com/pharmacy/pharmaceutics/33357/tablet-coating-not-only-a-technical-work-but-also-a-creative-art/lokhande-jyoti

internationaljournalsofcomputerscience, callforpapercomputerscience, ugcapprovedjournalsforcomputerscience 

Quality by Design is the modern approach for quality of pharmaceuticals. This paper gives idea about the Pharmaceutical Quality by Design QbD and describes use of Quality by Design to ensure quality of Pharmaceuticals. The Quality by Design is described and some of its elements identified. Process parameters and quality attributes are identified for each unit operation. Benefits, opportunities and steps involved in Quality by Design of Pharmaceutical products are described. The aim of the pharmaceutical development is to design a quality product and its manufacturing process to consistently deliver the intended performance of the product. Quality cannot be tested into products but quality should be built in by design. It includes the Quality target product profile, critical quality attributes and key aspects of Quality by Design. It also gives comparison between product quality by end product testing and product quality by Quality by Design. The foundation of Quality by Design is ICH Guidelines. It is based on the ICH Guidelines Q8 for pharmaceutical development, Q9 for quality risk management, Q10 for pharmaceutical quality systems. It also gives application of Quality by Design in pharmaceutical development and manufacturing of pharmaceuticals.

by Mr. Rajesh Dumpala | Ms. Jaini Bhavsar | Mr. Chirag Patil "Quality by Design: A Present to Future Perspective" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd32985.pdf 

Paper Url :https://www.ijtsrd.com/pharmacy/pharmaceutics/32985/quality-by-design-a-present-to-future-perspective/mr-rajesh-dumpala

peerreviewedinternationaljournal, callforpaperinugcapprovedjournals, paperpublicationforstudent

by Samadhan Mali | Shweta Gedam | Swati Talele | Anil Jadhav "Design and Development of Effervescent Floating Tablet Dapagliflozin" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020,

URL: https://www.ijtsrd.com/papers/ijtsrd31674.pdf

Paper Url :https://www.ijtsrd.com/pharmacy/pharmaceutics/31674/design-and-development-of-effervescent-floating-tablet-dapagliflozin/samadhan-mali

callforpaperphysics, physicsjournal