International Journal of Trend in Scientific Research and Development

Multiple sclerosis is a chronic inflammatory neurodegenerative disorder which directly affects Central Nervous System CNS . People with MS suffer with an episodic reversible memory loss during the initial stages and later it leads to the neurological deterioration. Number of research and studies has been done on the natural compounds and phytochemical compounds in order to develop the particular drug for the treatment of MS in vivo andin vitro. The present study focuses on the inhibitory effect of Rosmarinic acid against the effect of CD2 Associated protein with the help of Molecular Docking. Molecular Docking basically screens the ligand and the target protein and shows the interaction between them on the basis of the minimum binding affinities and drug likeliness properties. In our research, docking was performed between CD2 Associated protein and selected ligands with the help of docking software. Ligands were selected on the basis of their minimum Binding affinities and finally by their drug likeliness properties. Rosmarinic acid BA 5.6 was the resultant ligand of our recent study. It showed the perfect interaction with CD2 Associated protein. Therefore, we may conclude that Rosmarinic acid may act as a compound which may be used as a drug for the treatment of multiple sclerosis fromfurther in vitro and in vivostudies in future. 

by Jitin Kumar | Tejaswee Anand | Ritika Sharma | Noopur Khare | Abhimanyu Kumar Jha | Yamini Dixit "A Possible Role of Rosmarinic Acid against CD2-Associated Protein for the Treatment of Multiple Sclerosis through in Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd44979.pdf 

Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/44979/a-possible-role-of-rosmarinic-acid-against-cd2associated-protein-for-the-treatment-of-multiple-sclerosis-through-in-silico-approach/jitin-kumar

openaccessjournalofengineering, engineeringjournal, paperpublicationforengineering

In the present study, two plant species of the family Asteraceae were selected for an evaluation of their phytochemical screening, antioxidant and anti inflammatory properties. Phytochemical alkaloids, phenols, protein, flavonoids, quinines, tannins, and terpenoids are present in the aqua methanol and aqua acetone extract s of Cirsium arvense L Cronquist and Erigeron bonariensis. The selected plant species exhibit anti inflammatory properties in both solvents. The enzymatic antioxidant property of selected plant species was evaluated by superoxide dismutase SOD , peroxidase POD , and catalase CAT . E. bonariensis shows 20.05±0.02 superoxide dismutase activity which is moreover equal to C. arvense 19.47±0.31 . POD and CAT activities of C. arvense 109.35±0.69 and 41.48±0.13 and E. bonariensis 105.91±1.53 and 39.63±0.035 respectively, the POD activity of C. arvense is slightly higher than E. bonariensis but CAT activity again higher in E. bonariensis same as SOD. 

Deepti Rawat | P. B. Rao "Qualitative Phytochemical Screening and In-Vitro Assessment of Antioxidant and Anti-Inflammatory Potential of Aqua Methanol and Aqua Acetone Extract of Cirsium Arvense and Erigeron Bonariensis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd43934.pdf 

Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43934/qualitative-phytochemical-screening-and-invitro-assessment-of-antioxidant-and-antiinflammatory-potential-of-aqua-methanol-and-aqua-acetone-extract-of-cirsium-arvense-and-erigeron-bonariensis/deepti-rawat

peerreviewedjournals, reviewpapers, callforpaperhealthscience

Diabetes mellitus is an autoimmune disorder which causes impairment in the insulin secretion or resistance. The prevalence of Diabetes is increasing day by day worldwide, also this metabolic disorder diseases is associated with high risk of cardiac problem, obesity and many other diseases. Although, there are different medications and treatments are available but still they have proven to be ineffective and associated with severe adverse effects for long term. Therapeutic compounds based on herbal phytochemicals are considered as the most prominent for the treatments. The computational study helps in finding the structural basis analysis of the compounds by rapid screening tools with rational drug designing. This study aims to identify the natural inhibitor of Rad GTP binding protein to treat Diabetes dysfunctionality.Therefore, by searching the natural compounds against Rad GTPase binding protein with 2DPX structure, all the important data was retrieved by using online webservers followed by computing docking score in AutoDock Vina. Out of three selected compounds, Gedunin was used to dock with the protein 2DAX protein structure, as it follows the both criteria for proceeding further, one is to follow lowest binding criteria then ADME Absorption, Distribution, Metabolism and excretion . The docking score of Gedunin compound shows that, this bioactive agent can go against the Diabetes mellitus and inhibits the expression of Rad GTPase. By result Gedunin has shown its therapeutic role with 7.9 kcal mol value. It has been concluded that in future Gedunin may act as a novel drug target. 

Chanchal Prajapati | Varsha Prajapati | Mishka Tyagi | Noopur Khare | Abhimanyu Kumar Jha "Study of the Effect of Gedunin against Protein-GTP-Binding Protein RAD to Treat Diabetes: An In-Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd43888.pdf 

Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43888/study-of-the-effect-of-gedunin-against-proteingtpbinding-protein-rad-to-treat-diabetes-an-insilico-approach/chanchal-prajapati

ugcapprovedjournalswithlowpublicationfees, conferenceissuepublication

Diabetes is one of the major causes of death in the world, affecting around 422 million people or 8.5 percent of the worlds population . Diabetes mellitus, or diabetes, is a disease that causes excessive blood sugar levels. Diabetes mellitus is a condition where a person does not produce enough insulin or does not link directly to insulin, and resulting in excessively high blood sugar glucose levels. Diabetes is classified into several types Prediabetes, Type 1 diabetes, Type 2 diabetes and gestational diabetes. In diabetes research, numerous bioinformatics technologies are used. The current research was carried to study the effect of naturally occurring compounds against Aquaporin 2 as the target protein molecule with the help of molecular docking for diabetes diagnosis. AQP2 is found in the apical cell of the main ducts of the kidney and in the vesicles intracellular in the cells. Docking experiment were performed out by using aquaporin 2 4nef . The technique of molecular docking was utilized to investigate the potential of naturally occurring compounds such as aglycone, gedunin, and harman with the target protein Aquaporin 2 4nef . In diabetes, gedunin may function as a therapeutic drug against the disease causing protein Aquaporin 2 4nef . Further research and then certain clinical and pre clinical studies may be allowed to discover drugs that can be used to treat diabetes. 

Ayushi Chaudhary | Noopur Khare | Tripti Bhatnagar | Abhimanyu Kumar Jha "The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes: An In Silico Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd43788.

pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43788/the-role-of-gedunin-against-aquaporin-2-for-the-possible-treatment-of-diabetes-an-in-silico-study/ayushi-chaudhary

callforpapermathematics, mathematicsjournal, ugcapprovedjournalsinmathemetics

Breast cancer is the most frequently diagnosed cancer it has been treated for a long time with hormonal, medical assistance, surgery, chemotherapy, and irradiation. Natural compounds obtained for living organisms facilitate caspase mediated cell death and inhibit metastasis, so cancer growth is often prevented with greater efficacy. These compounds are often found to slow the progression of breast cancer. They improved patient survival rates and minimized the number of deaths caused by breast cancer. Apoptosis is defined as the death of cells that occurs as a natural and controlled part of an organisms growth or development. The production of membrane enclosed apoptotic bodies with well preserved organelles, as well as rapid cell condensation and budding. Within the process, there are certain morphological changes. The most important indicator of apoptosis induction is the presence of Cytotoxic anticancer agent. Some plant and natural chemicals promote apoptosis, which obstruct cancer cells through a variety of processes. 

by Komal Kaushik | Gunjan Choudhary | Akanksha | Vandana | Shweta Tyagi | Abhimanyu Kumar Jha "Potential of Natural Compounds in Treating Breast Cancer" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd42410.pdf 

Paper URL: https://www.ijtsrd.combiological-science/biotechnology/42410/potential-of-natural-compounds-in-treating-breast-cancer/komal-kaushik

callforpapertechnology, technologyjournal

An efficient plant regeneration protocol was developed for Santalum album L. Santalaceae , an economically important species. Plant regeneration was achieved using nodal explants and leaf disc on Murashige and Skoog MS medium for direct shoot regeneration. Effect of Plant Growth Regulators PGR like 6 Benzyl Adenine BA , Kinetin KN and 2 Isopentenyl adenine 2 iP on shoot initiation 2 Isopentenyl adenine and Gibberellic acid GA3 for shoot elongation and multiple shoot formation and Indole 3 Butyric Acid IBA and a Naphthalene Acetic Acid NAA for rooting was studied. Among the explants tested for shoot induction, nodal segments proved good results. The best treatment for obtaining shoot induction was 3.0mg L BAP and for rooting 1 mg L of IBA was found to be the best treatment combination for maximum sprouting of shoot and rooting. After six the rooted plantlets were transferred for hardening, 20 of plantlets survived and resumed growth in the mixture of soil, vermiculite and sand 1 1 1 . S. 

by Aghi Zion Inbakani | S. Sathishkumar | Bakan Jagdish Sudhakar "Micropropagation of Santalum Album L. (Sandalwood)" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd43698.pdf 

Paper URL: https://www.ijtsrd.combiological-science/biotechnology/43698/micropropagation-of-santalum-album-l-sandalwood/s-aghi-zion-inbakani

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Diabetes is a very serious, chronic, and complex metabolic disorder that is based on multiples aetiologies with both acute and chronic. There are two types of diabetes, one types 1 DM and the other is type two DM. Both T1DM and T2DM are the most serious type of chronic conditions that are typical cannot be cured. Insulin stimulates adipocytes, myocytes, and hepatocytes, which uptake glucose from the circulatory system. Antidiabetic drugs show useful effects through decreasing glucose absorption in the intestines increasing insulin levels in the body or increasing the bodys sensitivity or decreasing its resistance to insulin. Most of these plants contain bioactive compounds. Such compounds are alkaloids, flavonoids, glycosides, terpenoids, carotenoids, etc., which are frequently implicated as having an Antidiabetic effect. The different types of phytochemicals include flavonoids, saponins, phenolic acids, alkaloids, tannin, stillness, and polysaccharides. They have two types of drug design structure based drug desingand ligand based drug design. The protein is a structure based ligand, which is based on drug design for the role of significantly quantitative structure activity relationship QSAR and pharmacophore analysis. Ligand based pharmacophore model generation depends on the information regarding the known biological activity without any structural information depends on the macromolecular target. The ligand based VS is more expensive due to structure based methods. Based on the opposing chemical functionalities, and the geometric arrangement about each other, where the interactions are observed there is the pharmacophore features are placed on the ligand side.

by Niketa Singh | KM. Radha | Khushboo Rana | Fanish Kumar Pandey | Noopur Khare | Abhimanyu Kumar Jha "Bioinformatic Analysis of Selected Natural Compounds for Antidiabetic Potential" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd42419.pdf 

Paper URL: https://www.ijtsrd.combiological-science/biotechnology/42419/bioinformatic-analysis-of-selected-natural-compounds-for-antidiabetic-potential/niketa-singh

peerreviewedinternationaljournal, callforpaperinugcapprovedjournals, paperpublicationforstudent

The study aims at the screening of selected preservatives and additives with respect to its nutritional values. For centuries man has treated food to prolong to its shelf life, and now a days both the natural syntactic preservatives and additives are used widely to ensure the satisfactory maintenance of the quality, quantity and safety of foods. The food preservatives and additives are selected based on the food industries and purchased and measured. Nutrition values i.e., energy, carbohydrates, fats, proteins, fibre and sugar is analysed for the selective additives and preservatives. There continues to be lots of public concern about the use of food preservatives including additives leads from a perception that some of them may have undesirable effects on human body and their daily lifestyle. The absence of nutritional values in food additives and food preservatives are analysed by means of confirmatory tests. The results of these assays prove that there is no presence of nutrients in the additives and preservatives which are commonly used in south Indian food industries. 

by Keziah Prabhu | G. Sangavi | Shaleesha A. Stanley "Studies on the Common Preservatives and Additives and their Nutritional Values used in the South Indian Food Industry" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd42328.pdf 

Paper URL: https://www.ijtsrd.combiological-science/biotechnology/42328/studies-on-the-common-preservatives-and-additives-and-their-nutritional-values-used-in-the-south-indian-food-industry/keziah-prabhu

internationaljournalsinengineering, callforpaperengineering, ugcapprovedengineeringjournal 

Cancer is one of the deadliest diseases which is caused when abnormal cells divide uncontrollably and destroy body tissue. Colorectal cancer CRC , also known as colon cancer, is one of the most common type of cancers in humans is closely linked to the global cancer – related mortalities worldwide. The ongoing clinical treatment for colorectal cancer or colon cancer largely engages surgery and chemotherapy. But as there are many side effects and due to emergence of drug resistance, it has become very necessary to find novel and more effectual drugs for colon cancer treatment. Chemo prevention, a novel method for controlling cancer encompasses the use of specific natural products or synthetic chemical agents to reverse, suppress or prevent premalignancy before the development of invasive cancer. Many studies have signified that various natural products have efficacious anti CRC effects and may be used as substitutional chemotherapy agents for CRC therapy. Various natural compounds have been shown to be promising on the basis of their anti cancerous effects and low toxicity. In this review we summarise the natural compounds having anti CRC effects from distinct sources. This review suggest that they provide a novel opportunity for treatment of colon cancer.

by Sarita Negi | Nikita Kaushik | Runjhun Mathur | Abhimanyu Kumar Jha "Natural Compounds as Adjuncts for Treating Colon Cancer through Apoptotic Pathway" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd42387.pdf 

Paper URL: https://www.ijtsrd.compharmacy/biotechnology-/42387/natural-compounds-as-adjuncts-for-treating-colon-cancer-through-apoptotic-pathway/sarita-negi

internationaljournalofscience, openaccessjournalofscience, ugcapprovedjournalsforscience 

The most recent outbreak of the highly infectious acute respiratory syndrome SARS CoV 2 has grappled the world. Human behavior and awareness assessment during this crisis is crucial in an effort to contain the pandemic. Objectives We conducted this study to assess evaluation of awareness, attitude, prevention, expectations, and precautionary measures against COVID 19 among the university students in Odisha. Methods This is a comprehensive cross sectional study that was conducted as an online survey using an online self completed questionnaire. The participants were students enrolled in different universities in Odisha. The questionnaires were divided into four main sections general health knowledge, sterilisation, prevention, and precautionary measures on COVID19. Results Most of the students 85.8 believed that consuming antibiotics is not useful, 75.9 considered that washing hands with normal water is helpful and 61.8 believed drinking a hot drink will help prevent COVID 19. Where 54.7 of participants followed the world health organization as the primary sources of information and 27.4 of the participants used social media to obtain information about SARS CoV 2. Most of the participants 99 agreed that self isolation and maintaining distance can decrease the spread of COVID 19. The majority of the respondents had sufficient knowledge and their attitude and perception towards Covid 19 preventive measures was satisfactory. Conclusion Odisha Universities students demonstrated an expected level of awareness about the COVID 19 virus and implemented effective strategies to prevent its spread. 

by Haitham Haj Mohammed | Nibal Dibiat "Knowledge and Perceptions on COVID-19 among the University Students in Odisha: An Online Survey" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38416.pdf 

Paper Url: https://www.ijtsrd.com/biological-science/biotechnology/38416/knowledge-and-perceptions-on-covid19-among-the-university-students-in-odisha-an-online-survey/haitham-haj-mohammed

callforpaperarts, artsjournal, peerreviewedjournal

In December 2019, a series of patients with symptoms resembling viral pneumonia with unknown etiology detected in Wuhan, China. A novel coronavirus is identified by the disease symptoms which resembles two families of coronavirus and known as COVID 19. COVID 19 is a disease which is associated with the infection of SARS CoV 2. It becomes a pandemic disease globally because it spreads. CRISPR is a technology can be used for the diagnosis, which is a rapid, easy to implement and an accurate technology. CRISPR Cas protein based assay is used for the detection of SARS CoV 2 infection. CRISPR based assay is an alternative method for other diagnostic techniques like RT PCR assay because it is faster and more accurate than other techniques.

by Vijay Pratap Singh "Diagnosing Covid-19 by CRISPR Technology" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38400.pdf 

Paper Url: https://www.ijtsrd.com/biological-science/biotechnology/38400/diagnosing-covid19-by-crispr-technology/vijay-pratap-singh

callforpaperbiologicalscience, biologicalsciencejournal

Some people may have congenital or acquired biological or physical disabilities. For individuals in this situation, some positive developments are experienced with the advancement of technology. One of these developments can be considered today as BCI Brain Computer Interface .BCI systems can be divided into invasive and non invasive. Different techniques are used to obtain brain activities in non invasive BCI systems. Some of these techniques are EEG, ECoG, fNIRS, MEG, PET, MRI. Among these techniques, EEG and fNIRS are often preferred because of their easy applicability compared to other techniques. In this study, EEG based motor imagery BCI system is used. In this study, an experimental BCI system has been developed in which Turkish vowels that individuals say imaginatively are perceived over the EEG signal. In the methods section of this article, information is given about the experimental environment and techniques used in the study. The results obtained with the designed system are included in the results section. In the conclusion part, a general evaluation of the study is made and improvements that can be made to improve it are emphasized. 

by Kadir Haltas | Atilla Ergüzen | Erdal Erdal "A Study of EEG Based MI-BCI for Imaginary Vowels and Words" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd38165.pdf

Paper URL : https://www.ijtsrd.com/engineering/computer-engineering/38165/a-study-of-eeg-based-mibci-for-imaginary-vowels-and-words/kadir-haltas

callforpaperlifesciences, lifesciencesjournal, researchpapers

Laccase belongs to the blue multi copper oxidases, which are widely distributed in fungi and higher plants. Lignin degradation by several white rot fungi, such as Phanerochaete chrysosporium, Pleurotus ostreatus, Coriolus versicolor, Cyathus stercoreus, and Ceriporiopsis subvermispora, have been studied. Laccase enzymes have attracted attention due to its wide use in textile, pulp and paper, and food industry. Recently, it is being used in developing biosensors for detection and removal of toxic pollutants, designing of biofuel cells and medical diagnostics tool. Laccase is also being used as a bioremediation agent as they have been found potent enough in cleaning up herbicides pesticides and certain explosives in soil. Because of having the ability to oxidize phenolic, non phenolic lignin related compounds and highly fractious environmental pollutants, laccases have drawn the attention of researchers in the last few decades. Commercially, laccases have been used to determine the difference between codeine and morphine, produce ethanol and are also being employed in de lignify woody tissues. To sustain this trend widespread availability of laccase and efficient production systems have to be developed. The current review discuss major advances in application of fungal laccase in white biotechnology. It delineate the laccase production and various cultivation techniques that have been developed to efficiently produce laccase at the industrial scale. The role of laccase in different food industries, and significant recent advances in the use of laccases are discussed in this review. 

by Sonal K. Makwana | Rakeshkumar R. Panchal | Kiran C. Deshmukh "Fungal Laccase - A Review on Production and its Potential Application for Human Welfare" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-1 , December 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd38221.pdf

Paper URL : https://www.ijtsrd.com/biological-science/biotechnology/38221/fungal-laccase--a-review-on-production-and-its-potential-application-for-human-welfare/sonal-k-makwana

callforpapertechnology, technologyjournal

by Dharmpal Meet A | Rathod Zalak R "Role of Copper in Environment as a Potential and Challenges" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd33515.pdf

Paper Url: https://www.ijtsrd.com/biological-science/biotechnology/33515/role-of-copper-in-environment-as-a-potential-and-challenges/dharmpal-meet-a

callforpapercommerce, ugcapprovedjournalsincommerce, commercejournal

by Mounica U | Pooja S | Senthil J | Janakidevi V "Anticancer Activity of Some Medicinal Plants: A Review" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-6 , October 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd35751.pdf

Paper Url: https://www.ijtsrd.com/biological-science/biotechnology/35751/anticancer-activity-of-some-medicinal-plants-a-review/mounica-u

peerreviewedjournals, reviewpapers, callforpaperhealthscience

Echinacea purpurea L. is a herbaceous flowering plant. It is lie in eastern and central North America. E.purpurea acts as anti inflammatory and antiviral components include polyphenols such as polyvinylpolypyrroliodone PVPP , polysaccharides, glycoproteins, cichoric acid 2,3 O dicaffeoyl tartaric acid ,alkylamides and caffeic acid derivatives. These compounds help in direct virucidal activity such as influenza virus A and B, Para influenzae viruses, Corona viruses and Adenoviruses and anti inflammatory effects against several respiratory diseases, affects on the pro inflammatory response of epithelial cells and reduction of mucin by airways cells These bioactive compounds is characterized for further improvements in the efficacy of Echinacea purpurea. 

by Dr. Priyanka Gupta "A Review on Echinacea Purpurea L. (Purple Coneflower) Bioactive Compounds used as Belligerent" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, 

URL: https://www.ijtsrd.com/papers/ijtsrd31716.pdf 

Paper Url :https://www.ijtsrd.com/biological-science/biotechnology/31716/a-review-on-echinacea-purpurea-l-purple-coneflower-bioactive-compounds-used-as-belligerent/dr-priyanka-gupta

ugcjournallist, listofugcapprovedjournals, researchpublication