The brain is a delicate organ, and evolution built very efficient ways to protect it. Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Many existing pharmaceuticals are rendered ineffective in the treatment of cerebral diseases due to our inability to effectively deliver and sustain...
Showing posts with label Analytical Chemistry. Show all posts
Showing posts with label Analytical Chemistry. Show all posts
Saturday, 11 September 2021
Wednesday, 8 September 2021
Method Development and Validation for Estimation of Oral Hypoglycaemic Drug Dapagliflozinina Tablet Dosage form by the Employment of Rp HPLC
Team IJTSRD
September 08, 2021
0
HPLC is a chromatographic technique employed in active compound chemistry and biochemistry to separate a mixture and substances with the goal of identifying, measuring, and purifying the different components of the mixture. Its a much better variety of column and traditional chromatography. The objective of the research work is to develop and validate a simple...
Monday, 6 September 2021
Stability Indicating HPLC Method Development A Review
Team IJTSRD
September 06, 2021
0
High performance liquid chromatography is most powerful tools in analytical chemistry which assessing drug product stability. It is most accurate method for determining the qualitative and quantitative analysis of drug product. Forced degradation plays an important role in development of stability indicating analytical methodology. Stability indicating HPLC...
Sunday, 5 September 2021
Stability Indicating RP HPLC Method Development and Validation of Everolimus in Bulk and Pharmaceutical Dosage Form
Team IJTSRD
September 05, 2021
0
Everolimus is semisynthetic derivative of sirolimus, which is isolated from Streptomyces hygroscopicus. A novel reversed phase high performnce liquid chromatography HPLC method for determination of the everolimus in the presence of degradation product or pharmaceutical excipients. Seperation was carried out using Cosmosil C18 250mm x 4. 6ID , column having particle...
Curcumin Based Nanotherapy of Cancer A Review
Team IJTSRD
September 05, 2021
0
Cancer is the most prevalent disease not only in the United States but worldwide. The most representative polyphenol component extracted from the rhizomes of Curcuma long a known as turmeric is curcumin. The therapeutic benefits of curcumin have been demonstrated in multiple chronic diseases inflammation, arthritis, metabolic syndrome, liver disease, obesity,...
Thursday, 10 December 2020
Application of Hydrotrophy in HPLC Hydrotrophic Solution, A Novel Cost Effective and Eco Friendly Mobile Phase for Solubilization of Poorly Water Soluble Drugs
Team IJTSRD
December 10, 2020
0
Hydrotrophy is a unique molecular phenomenon that posses the ability to increase the solubility of sparingly soluble and poorly soluble drugs in water. A hydrotrophic solution can be defined as adding a solute, that is Hydrotrope, eg urea to the primary one solvent and is used as mobile phase for HPLC. High solubility, easy availability, cost effectiveness,...
Thursday, 24 September 2020
Review Article on Valsartan
Team IJTSRD
September 24, 2020
0
A simple, sensitive, rapid and reproducible HPLC method has been developed and validated for Calibration determination of Valsartan in bulk and in pharmaceutical formulation by applying Quality intentionally. For development of HPLC method for Valsartan various trials are performed by using Design Expert software by applying 3 level factorial designs. Quantitative...
Friday, 8 May 2020
Current Status and Future Perspective of Rapid Diagnostic Kits Vaccine against COVID 19
Team IJTSRD
May 08, 2020
0
Coronavirus disease 2019 COVID 19 , which causes serious respiratory illness such as pneumonia and lung failure, was first reported in Wuhan, the capital of Hubei, China. The etiological agent of COVID 19 has been confirmed as a novel coronavirus, now known as severe acute respiratory syndrome coronavirus 2 SARS CoV 2 , which is most likely originated from...
Monday, 16 December 2019
RP-HPLC Method Developed for the Estimation of Etodolac and Thiocolchicoside in Bulk and Combined Dosage Forms
Team IJTSRD
December 16, 2019
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A new, simple, specific, sensitive, rapid, accurate and precise RP HPLC method was developed for the estimation of Etodolac ETO and Thiocolchicoside THIO in bulk and combined pharmaceutical dosage forms. Etodolac ETO and Thiocolchicoside THIO was chromatographed on a Symmetry ODS C18 4.6mm—250mm, 5µm Column in a mobile phase consisting of Acetonitrile Methanol...
Development and Validation of Analytical Methods for Simultaneous Spectrophotometric Determination of Pioglitazone and Glimepiride by Derivative Method
Team IJTSRD
December 16, 2019
0
A simple, rapid UV Visible spectrophotometric method for the quantification of Pioglitazone hydrochloride and Glimepiride in bulk drug and tablet formulation was developed and validated. UV Visible spectrophotometric methods have been developed for the Derivative Spectrophotometric Method, of Pioglitazone and glimepiride in bulk and pharmaceutical dosage...
Friday, 22 November 2019
Determination of Etodolac in Commercial Formulations by HPLC-UV Method
Team IJTSRD
November 22, 2019
0
The aim of this study was to develop and verify a simple, rapid and sensitive high performance liquid chromatography method coupled with UV detector HPLC UV method for the quantitative determination of etodolac in bulk and pharmaceutical dosage forms. Chromatographic separation was performed at ambient conditions on a reverse phase ACE C8 analytical column...
Sunday, 20 October 2019
Development and Validation of RP HPLC Method for Estimation of Vortioxetine in Bulk and Pharmaceutical Dosage Form
Team IJTSRD
October 20, 2019
0
A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the validated of Vortioxetine in its pure form as well as in tablet dosage form. Chromatography was carried out on ODS C18 4.6 x 250 mm, 5µm column using Acetonitrile And Methonal 70 30 as the mobile phase at a flow rate of 1.0 mL min, the detection was...
Wednesday, 16 October 2019
Development and Validation of an RP HPLC Method for Analysis of Sitagliptin
Team IJTSRD
October 16, 2019
0
Sitagliptin is a drug used against type 2 diabetes mellitus and it is a member of class of anti diabetic drugs known as dipeptidyl peptidase 4 inhibitors or gliptins . A simple, sensitive and accurate RP HPLC method has been developed for the determination of Sitagliptin in bulk formulation. The max of the Sitagliptin was found to be 267nm in Methanol phosphate...
Friday, 9 August 2019
Review Conductivity of Water Purified and SWFI at Different pH and Temperatures
Team IJTSRD
August 09, 2019
0
This paper in particular mainly concerns with the conductivity of water used in pharmaceutical preparation, i.e. purified water and SWFI sterile water for injection . This paper is focused on the variation of conductivity of the water purified and SWFI with the change in pH and temperature.
by Faiz Hashmi ""Review: Conductivity of Water (Purified...
Anti Microbiological Assay Test or Antibiotic Assay Test of Pharmaceutical Preparation Containing Antibiotics using 'Cylinder Plate Method'
Team IJTSRD
August 09, 2019
0
In this paper, we are going to discuss the anti microbiological assay of the antibiotics. Aim of this paper is to predict the potency of the antibiotic preparation in reference with the working standard of the antibiotic and using the mathematical model in order to obtain the potency of the preparation in regards to its claim.
by Faiz Hashmi ""Anti-Microbiological...
Sunday, 14 July 2019
Analytical Method Development and Validation for the Estimation of Zolmitriptan by RP HPLC Method
Team IJTSRD
July 14, 2019
0
In this work the authors have proposed a simple, specific, economic and accurate reverse phase liquid chromatographic method for the estimation of Zolmitriptan as an active pharmaceutical ingredient and in pharmaceutical formulation. The main objective of the current research paper is to To develop simple, precise and accurate RP HPLC method for Zolmitriptan...
Saturday, 13 July 2019
Nutritive Evaluation, Mineral Composition and Phytochemical Analysis of Leaf Protein Concentrates of Daucus carota
Team IJTSRD
July 13, 2019
0
Fresh green leaves of Daucus Carota was harvested and processed with a view to analyse its photochemical constituents and nutritional potentials. Proximate analysis, mineral analysis and phytochemical analysis was determining using standard analytical techniques. The nutrient composition of the leaf protein concentrate revealed Moisture content 8.69±0.03...
Monday, 6 May 2019
Analytical Methods Development and Validation of Naproxen and Sumatriptan by RP HPLC
Team IJTSRD
May 06, 2019
0
Aim and objective A simple, précised, accurate method was developed for the estimation of Crizotinib by RP HPLC technique. Chromatographic conditions used are stationary phase BDS 250x4.6 mm, 5µ. Mobile phase buffer Methodology Acetonitrile in the ratio of 60 40 and flow rate was maintained at1ml min, detection wave length was 267 nm, column temperature...
Monday, 25 March 2019
Solvent Extraction and Spectrophotometric Determination of Nickel II using 2 "“ Hydroxy 1 Naphthaldehyde Thiosemicarbazone HNT as an Analytical Reagent
Team IJTSRD
March 25, 2019
0
2 – hydroxy 1 naphthaldehyde thiosemicarbazone HNT is synthesized in laboratory and characterized by NMR, IR and elemental analysis for its purity. This reagent forms a yellowish green coloured complex with Ni II which can be quantitatively extracted into ethyl acetate at pH 7. Complex in ethyl acetate shows an intense absorption peak 430 nm. It is observed...
Tuesday, 12 March 2019
Analytical Method Development and Validation of Metformin Hydrochloride by using RP HPLC with ICH Guidelines
Team IJTSRD
March 12, 2019
0
A simple and reproducible method was developed for Metformin MET by Reverse Phase High Performance Liquid Chromatography RP HPLC . Metformin was separated on C18 column 4.6x250mm, particle size 5µm , using combination of phosphate buffer with pH of 3.0 and Methanol at the UV detection of 238nm. Isocratic elution of phosphate buffer with pH of 3.0 and Methanol...
