The biological methods for synthesis of nano particles by using various microorganisms, enzymes, plants, and their extracts have been suggested as the probable and promising eco friendly alternatives to the chemical and physical methods of synthesis. The bio compatibility of nano particles is more essential for specific biomedical applications and researches. The aim of this study was to evaluate the effect of ZnO nano particles for anticancer and antimicrobial activity. In this study ZnO Nano particles were synthesized by Bacillus subtilisu sing Zinc acetate dihydrate as substrate and sodium borohydride as reducing agent.
The preliminary confirmation of the presence of the nano particles was the formation of precipitate and white coloration in the final mixture. The confirmation of the presence of nano particles was carried out by SEM analysis. The antimicrobial activity of nano particles was determined by well diffusion method and also the synergistic effect of nano particles with antibiotics on bacteria was determined by well diffusion method. The anticancer activity of the nano particles on MDA MB321 (human breast cancer cells) was determined by MTT assay.
By Hanumith. S | Mahalakshmi. V | Abirami. S" Biosynthesis of Zinc Oxide Nanoparticles Using Bacillus Species Potentiates Anticancer and Antimicrobial Activity"
Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-5 , August 2018,
Paper URL: http://www.ijtsrd.com/papers/ijtsrd17137.pdf
Direct URL: http://www.ijtsrd.com/biological-science/microbiology/17137/biosynthesis-of-zinc-oxide-nanoparticles-using-bacillus-species-potentiates-anticancer-and-antimicrobial-activity/hanumith-s
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