Development and Stability Enhancement of Two Combine Drugs of Cetirizine and Ambroxol

Ambroxol Hydro chloride and Cetirizine Hydro chloride are often prescribed together for greater patient acceptability, increased potency, multiple activity, fewer side effects and quick relief. Ambroxol Hydro chloride and Cetirizine Hydrochloride are used for the treatment of bronchitis, cough, and allergy. Conventional Ambroxol and Cetiri zine tablet available in the market are not suitable in certain cases such as motion sickness, sudden episodes of allergic attacks, or coughing and when drinking water is not available. 

Particularly these types of difficulty are faced by pediatric and geriatric patients. An attempt has been made to develop and enhance the stability of two combine drugs Ambroxol Hydro chloride and Cetirizine Hydro chloride, we prepared fast disintegration tablets. Total six formulations (F1'“F6) were prepared to study the effect of superdisintegrants shown in Table I. Tablets were prepared by the technique of direct compression methods. Required quantity of each ingredient was taken for each specified formulation. 

The superdisintegrant, sodium starch glycolate (1%, 2%, 4%, 6%, 8%, and 10%) concentration was used to develop the tablets. All the ingredients were passed through mesh size # 60. All the ingredients were cogrind in a pestle motor. Finally talc and Sodium Stearyl fumarate were added and mixed for 5 minutes. The blended excipients were compressed into tablets using tablet compression machine (Madhur Industries, India). The dissolution studied results revealed that in both of the drug Ambroxol Hydro chloride and cetirizine hydro chloride in phosphate buffer pH 6.8 and pH 7.4 dissolution medium were shown within the specified Pharmacopoeias limit. 

By Natasha Johar | Tulshi Chakraborty | Vipin Saini" Development and Stability Enhancement of Two Combine Drugs of Cetirizine and Ambroxol" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4 , June 2018,

Paper URL: http://www.ijtsrd.com/papers/ijtsrd14468.pdf 

Direct URL: http://www.ijtsrd.com/pharmacy/other/14468/development-and-stability-enhancement-of-two-combine-drugs-of-cetirizine-and-ambroxol/natasha-johar

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