International Journal of Trend in Scientific Research and Development

Background The main pathophysiology of diabetes mellitus DM is oxidative stress, which is an imbalance between production of free radicals and antioxidant system in the body. Persistent hyperglycemia causes increased production of free radicals especially reactive oxygen species ROS , in tissues from glucose auto oxidation and protein glycosylation. Aim To investigate the comparative effect of Aloe vera gel, rind and a combination of gel and rind on the oxidative stress in alloxan induced diabetic rats. Materials and Methods 25 male wistar rats weighing between 220-260g were used for this study. They were divided into five groups A E of 5 rats each. Group A served as positive control group and received distilled water only. Group B was the negative diabetic group with no extract administration. Groups C, D and E were diabetic groups that received 300mg kg of Aloe vera rind, 300mg kg of Aloe vera gel and combination of 150mg kg of Aloe vera rind and 150 mg kg of Aloe vera gel respectively. Extract administration was done orally, once daily for 14 days. At the end of administration, oxidative stress biomarkers were assessed. Results There was significant decrease in SOD level in group B 9.87±0.20 when compared with the control 15.88±0.39 . Conversely, groups C 17.50±0.35 and D 17.94±0.22 showed significant increase when compared with the control. However, group E showed no significant change when compared with the control 15.88±0.39 . On the other hand, there was significant increase in SOD in control group A 15.88±0.39 and all the test groups when compared with group B 9.87±0.20 . Similarly, a significant increase in MDA was observed in group B 5.39±0.20 when compared with the control 4.15±0.21 . Groups C 3.62±0.20 and D 3.23±0.12 showed significant decrease when compared with control 4.15±0.21 . Furthermore, group E 4.14±0.26 showed no significant difference when compared with the control 4.15± 0.2 . On the other hand, groups A and all the test groups showed significant decrease in MDA when compared with group B 5.39±0.20 . Conclusion Aloe vera gel and Aloe vera rind extracts singly appeared more potent in reducing oxidative stress in diabetic rats when compared to combined extracts of Aloe vera rind gel at lower doses. 

by M. C. Igbokwe | V. U. Igbokwe | N. N. Njoku-Oji | C.O.J Okonkwo "Comparative Effect of Aqueous Aloe Vera Extracts on Oxidative Stress in Alloxan-Induced Diabetic Wistar Rats" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd46381.pdf 

Paper URL : https://www.ijtsrd.com/humanities-and-the-arts/philosophy/46381/comparative-effect-of-aqueous-aloe-vera-extracts-on-oxidative-stress-in-alloxaninduced-diabetic-wistar-rats/m-c-igbokwe

callforpapercommerce, ugcapprovedjournalsincommerce, commercejournal

The article examines the philosophical views and teachings of Central Asian thinkers on the formation of the ecological culture of the individual. Islamic teachings also pay special attention to the ontological problems of the ecological worldview, ie the question of the origin of nature. The article provides an in depth analysis of important scientific data that enrich the individuals ecological outlook. The author provides an opportunity to scientifically study the ecological culture of the individual and the role of religious values in it. 

by Kilichov Feruzbek "The Teachings of Central Asian Thinkers on the Formation of Personal Ecological Culture" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd41165.pdf 

Paper URL: https://www.ijtsrd.comhumanities-and-the-arts/philosophy/41165/the-teachings-of-central-asian-thinkers-on-the-formation-of-personal-ecological-culture/kilichov-feruzbek

callforpaperpharmacy, pharmacyjournal, internationalpeerreviewedjournal

The article examines the emergence of the science of sociolinguistics, role in the area of linguistics. About the researchers who contributed to the development of science and their scientific activities. 

by Rayhona Numonovna Nuritdinova "The Formation of Sociolinguistics as a Science and a Place in Linguistics" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | International Research Development and Scientific Excellence in Academic Life , March 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38754.pdf 

Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/philosophy/38754/the-formation-of-sociolinguistics-as-a-science-and-a-place-in-linguistics/rayhona-numonovna-nuritdinova

internationaljournalsofcomputerscience, callforpapercomputerscience, ugcapprovedjournalsforcomputerscience 

In this article, the formation of an ecological worldview in the world is not only a deterrent to global problems, but also means for environmental security, the solution of which takes place with the participation of human consciousness, reflection, intellect, intellectual potential and whole values and its ontological, epistemological, philosophical aspects within the Aral Sea region are analyzed. 

by Jumaniyaz Ramatov | Rozigul Umarova "Constructive and Optimal Solutions for the Formation of a Stable Ecological Situation in the Aral Sea Region of Uzbekistan" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | International Research Development and Scientific Excellence in Academic Life , March 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38753.pdf 

Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/philosophy/38753/constructive-and-optimal-solutions-for-the-formation-of-a-stable-ecological-situation-in-the-aral-sea-region-of-uzbekistan/jumaniyaz-ramatov

internationaljournalsofcomputerscience, callforpapercomputerscience, ugcapprovedjournalsforcomputerscience 

This article analyzes the socio political movements of the Young Khiva people in the Khiva Khanate in the early twentieth century.In particular, it is also mentioned about the fact that the revolution in Russia has a positive impact on the growth of movements towards democratic reforms in Turkestan.From the beginning of 1917 the movement for democratic reform was began in the Khiva khanate. The young Khiva people whoarmed with the idea of independence took an active part in this movement with the idea of changing the political situation in the khanate and implementing some democratic reforms. 

by Bakhtigul Abdupattaevna Mamadaminova "Some Considerations about the Socio-Political Movements of Young Khivans" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Special Issue | Innovative Development of Modern Research , April 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd39941.pdf

Paper URL : https://www.ijtsrd.com/humanities-and-the-arts/philosophy/39941/some-considerations-about-the-sociopolitical-movements-of-young-khivans/bakhtigul-abdupattaevna-mamadaminova

openaccessjournalofengineering, engineeringjournal, paperpublicationforengineering

The recurrence of animal to man pathologies and its lethality has motivated our inquiry into a rethink of our relationship with fauna species. Mindful of the lethality of zoonoses, the duration to develop vaccines for the prevention of zoonoses, the inevitable interaction of fauna and humans, the fragile nature of the human immune system to fight zoonoses, this paper proposes a “zooimmunocament” which humanity needs to borrow the genetic and immunologic ingredients from the fauna species where they don’t develop a malady and used for his therapy. This therapy is far from vaccines. Humanity thanks to his evolutionary advancement in intelligence can control and make use of the fauna immune system for the fight against zoonotic zoonoses pathologies. Since those pathogens in fauna species do not cause harm, humanity can exploit the set up of their defense system for a possible therapy thus the appellation zooimmunocament. 

by Ezekiel Kikoh | Ngai Roland Yinkfu "Zoonoses-pandemics and the Urgency of a “Zooimmunocament”" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38457.pdf 

Paper Url: https://www.ijtsrd.com/humanities-and-the-arts/philosophy/38457/zoonosespandemics-and-the-urgency-of-a-“zooimmunocament”/ezekiel-kikoh

peerreviewedinternationaljournal, paperpublicationforstudent