International Journal of Trend in Scientific Research and Development: Pharmacology

International Journal of Trend in Scientific Research and Development

IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas. For any further information, feel free to write us on editor.ijtsrd@gmail.com

  •
    • Showing posts with label Pharmacology. Show all posts
    Showing posts with label Pharmacology. Show all posts

    Thursday, 21 October 2021

    Interplay between Follicle Stimulating Hormone FSH , Luteinizing Hormone LH and Prolactin in Hyperprolactinaemic Infertile Women Treated with Cabergoline in Orlu, Nigeria

    October 21, 2021 0
    Interplay between Follicle Stimulating Hormone FSH , Luteinizing Hormone LH and Prolactin in Hyperprolactinaemic Infertile Women Treated with Cabergoline in Orlu, Nigeria
    The study evaluated the interplay between Follicle stimulating hormones, Leutenizing hormone, and prolactin in hyperprolactinaemic infertile female subjects treated with cabergoline in Orlu, South East Nigeria. Hyperprolactinaemic females who were attending Gynaecology Clinic at Imo State University Teaching Hospital IMSUTH Orlu participated in the study. 30 hyperprolactinaemic females were administered 0.25mg cabergoline twice weekly for eight weeks. Serum prolactin, LH and FSH were assayed before and after treatment using enzyme linked immunesorbent assay ELISA kits. The significant difference between the mean values of prolactin, LH and FSH in the pre and post treatment with cabergoline was determined by paired t test. There was an inverse relationship between prolactin level and FSH and LH before and after treatment. Linear regression analysis showed that for every 0.14 and 0.02 unit change in the level of pretreatment prolactin, there is 1 unit change in FSH and LH level respectively. While for every 0.25 and 0.31 unit change in level of post treatment prolactin, there is 1 unit change in the level of FSH and LH respectively. Only change in post treatment LH following change in post treatment prolactin was statistically significant, and the P value 0.05, however, others were not statistically significant. 
    by Ajaero, Oluchi Chinwe | Offiah, Raymond Ogbonna | Unekwe, Prince Chiazor | Ajaero, Nnaemeka Uchendu | Uzoma, Onyeka I. "Interplay between Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Prolactin in Hyperprolactinaemic Infertile Women Treated with Cabergoline in Orlu, Nigeria" 

    Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-6 , October 2021, 
    Posted by at No comments:
    Labels:

    Sunday, 29 August 2021

    Review of the Diagnosis and Treatment of Paralysis

    August 29, 2021 0
    Review of the Diagnosis and Treatment of Paralysis

    Paralysis is a complete loss of motor power in any muscle group. When paralysis affects all four extremities, it is called quadriplegia when it affects only the lower extremities, paraplegia and when it affects the extremities on one side of the body, hemiplegic. For this reason, the term paralysis is generally reserved for more focal, less stereotyped weakness, for instance, affecting all the muscles innervated by a peripheral nerve. Many different anatomical lesions and etiologies can cause paralysis and determine its treatment. 

    by Bikash Debsingha | Dr. Gourav Kr. Sharma | Dr. Kausal Kishore Chandrul "Review of the Diagnosis and Treatment of Paralysis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

    URL: https://www.ijtsrd.com/papers/ijtsrd45108.pdf 

    Paper URL: https://www.ijtsrd.com/pharmacy/pharmacology-/45108/review-of-the-diagnosis-and-treatment-of-paralysis/bikash-debsingha


    callforpaperarts, artsjournal, peerreviewedjournal 
    Posted by at No comments:
    Labels:

    Thursday, 4 February 2021

    Transgenic Animals A Better Approach towards Experimentation

    February 04, 2021 0
    Transgenic Animals A Better Approach towards Experimentation

    Animals play a crucial role in the development of medical products from medicines to various implants and major surgical procedures. They are not approved for human use until they qualify the safety parameters in animals. The animals play a pivotal role in drug discovery and development. One of the most challenging aspects of targeting drugs for any pathological condition is the development of animal models. Animal models are nothing but an approach to replicate the general symptoms of the diseased condition which occur in humans. The whole pathophysiology cannot be replicated but, the symptoms which are known and precipitate the most in any pathological condition are positively reproduced within the animal. With the increasing need in the medical field, the paradigm is now slowly shifting towards transgenic animals as they have given a new dimension to medical sciences to study the pathophysiology of the disease rather than focusing on the symptom based analysis of the diseased condition. These genetically modified organisms have shown groundbreaking results not only in developing models for various diseases but also in developing biopharmaceuticals, receptor selective drugs, and have a huge contribution to xenotransplantation and the agriculture sector. This review article vividly describes the newer approaches that are adopted to develop transgenic animal models and also highlights certain limitations to the older approach of developing the models. 

    by Swarnima Negi | Dr. Sachdev Yadav "Transgenic Animals: A Better Approach towards Experimentation" 

    Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

    URL: https://www.ijtsrd.com/papers/ijtsrd38268.pdf 

    Paper Url: https://www.ijtsrd.com/pharmacy/pharmacology-/38268/transgenic-animals-a-better-approach-towards-experimentation/swarnima-negi

    callforpapermedicalscience, medicalsciencejournal
    Posted by at No comments:
    Labels:

    Wednesday, 22 July 2020

    Studies on Phytochemicals, Antioxidant and Anticancer Potentials of Evolvulus Alsinoides using Lung Cancer Cell Line

    July 22, 2020 0
    Studies on Phytochemicals, Antioxidant and Anticancer Potentials of Evolvulus Alsinoides using Lung Cancer Cell Line

     The main objective of this study was to evaluate the phytochemicals, antioxidant potentials and anticancer property of Evolvulus alsinoides. Initially, plant extract was prepared using different solvents includes petroleum ether, ethanol and ethyl acetate. The antioxidant potential of the selected plant extract was assessed by Super oxide radical assay, Hydroxyl radical assay and DPPH assays and the results were analyzed. The anticancer property was observed against lung cancer cell line, A 549. From the results it was found that, Alkaloids, Steroids, Flavonoids, Tannins Phenol, Proteins, Carbohydrate and Glycosides are present in the ethanolic extract of the plant. No significant compounds could be detected in other extracts including petroleum ether and ethyl acetate. DPPH assay and Ferric thiocyanate method clearly reveals that, this plant extract has significant antioxidant potential in dose dependent manner. It also showed notable inhibitory potential against the growth of the lung cancer cells. 

    by Shaleesha A. Stanley | T. Yazhini "Studies on Phytochemicals, Antioxidant and Anticancer Potentials of Evolvulus Alsinoides using Lung Cancer Cell Line" 

    Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, 

    URL: https://www.ijtsrd.com/papers/ijtsrd31804.pdf 

    Paper Url :https://www.ijtsrd.com/pharmacy/pharmacology-/31804/studies-on-phytochemicals-antioxidant-and-anticancer-potentials-of-evolvulus-alsinoides-using-lung-cancer-cell-line/shaleesha-a-stanley

    openaccessjournalofengineering, engineeringjournal, paperpublicationforengineering
    Posted by at No comments:
    Labels:

    Friday, 14 February 2020

    A Comprehensive Review on Clinical Pharmacology of Non Steroidal Anti Inflammatory Drugs

    February 14, 2020 0
    A Comprehensive Review on Clinical Pharmacology of Non Steroidal Anti Inflammatory Drugs
    An increasing number of non steroidal anti inflammatory drugs NSAIDs is available for clinical use each year. This article reviews significant differences between NSAIDs currently available in worldwide, and helps the clinician to evaluate new NSAIDs. While their mechanism of action and efficacy are similar, side effects and cost vary considerably from one agent to another. Because all NSAIDs can produce adverse effects, patients, especially if they are elderly, should be selected carefully for treatment with a particular agent. 

    by Sachin Korde | Jugal Vyas ""A Comprehensive Review on Clinical Pharmacology of Non-Steroidal Anti-Inflammatory Drugs""

    Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-2 , February 2020,

    URL: https://www.ijtsrd.com/papers/ijtsrd30018.pdf

    Paper Url : https://www.ijtsrd.com/pharmacy/pharmacology-/30018/a-comprehensive-review-on-clinical-pharmacology-of-non-steroidal-anti-inflammatory-drugs/sachin-korde

    callforpaperarts, artsjournal, peerreviewedjournal
    Posted by at No comments:
    Labels:

    Monday, 23 December 2019

    Evaluation of Prescribing Patterns of Antibiotics in General Medicine Ward in a Tertiary Care Hospital

    December 23, 2019 0
    Evaluation of Prescribing Patterns of Antibiotics in General Medicine Ward in a Tertiary Care Hospital

    Knowledge about antibiotic utilization and resistance patterns of most common microorganisms are unavailable in tertiary care hospitals. To assess the pattern of antibiotic utilization and outcome of patients in a General Medical Ward, all positive blood cultures BC over a 4 month period from July 2019 to October 2019 were retrospectively reviewed. Sixty five positive BC were recorded in which patients 43 males and 22 females . 72 of the patients received antibiotics before or soon after obtaining the BC, and ceftriaxone was the most frequently prescribed antibiotic 41.93 , either alone or in combination with other antibiotics. The bacteraemia was due to gram positive cocci in 60.46 of cases, gram negative rods in 30.23 , and gram positive rods in 9.30 . Positive BC due to contamination was not included. The most common gram positive cocci were Staphylococcus epidermidis, followed by S. aureus, while the most common gram negative bacilli were Brucella species, Proteus mirabilis, and Klebsiella sp. The suspected sources of the bacteraemia were respiratory 21.2 , urinary 19.2 , or skin 19.2 . A subsequent change in the antibiotics regimen was done in 69.76 cases after BC results became available with no apparent effect on the outcome. Adding Cefotaxime, Amoxicillin clavulonic acid, piperacillintazobactum, vancomycin and clindamycin was the most frequent change done 19.4 for each equally . Complications developed in 69.76 of patients, with 88.66 of them suffering from sepsis shock. 69.23 of the patients improved and 30.77 expired death was related to infection in 87.5 of cases. In conclusion, most bacteremia in the medical ward of the hospital were due to gram positive cocci, which should be considered in antibiotic selection prior to BC. 


    by Vageeshwari Devuni | Debabrata Chaudhary "Evaluation of Prescribing Patterns of Antibiotics in General Medicine Ward in a Tertiary Care Hospital"

    Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019,

    URL: https://www.ijtsrd.com/papers/ijtsrd29618.pdf 

    Paper URL: https://www.ijtsrd.com/pharmacy/pharmacology-/29618/evaluation-of-prescribing-patterns-of-antibiotics-in-general-medicine-ward-in-a-tertiary-care-hospital/vageeshwari-devuni

     call for paper arts, ugc approved journals for social science, commerce journal
    Posted by at No comments:
    Labels:

    Tuesday, 2 July 2019

    Herbal and Synthetic Drug Combinations in Cancer Therapy A Review

    July 02, 2019 0
    Herbal and Synthetic Drug Combinations in Cancer Therapy A Review

    Cancer is one of the leading and most serious diseases in the current decade, every year millions of people die because of various kinds of cancers. Many aspects relate to the cause of disease besides heredity, food habits, smoking, nutritional behaviors, radiation etc. Cancer is a high mortality disease and the therapeutics for cancer, especially for cancer metastasis is still imperfect. The successful cancer treatment till now has been under study, only chemotherapy and radiation treatments are at times successful. Alternative and less toxic medication is very much in need towards the disease, the use of concepts of herbal medicine with synthetic drug could present better drug leads towards the inhibitory treatment of Cancer. Nature shows plethora of medicinal plants with anticancer and antioxidant activities which may suppress the disease completely. By applying combination therapy instead of monotherapy can lead to improved efficacy and reduced toxicity of the conventional method of treatments of cancer. 


    by Anusree S | Dr. Silvia Navis A | Dr. Prashob G R ""Herbal and Synthetic Drug Combinations in Cancer Therapy- A Review""

    Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019,

    URL: https://www.ijtsrd.com/papers/ijtsrd25222.pdf

    Paper URL: https://www.ijtsrd.com/pharmacy/pharmacology-/25222/herbal-and-synthetic-drug-combinations-in-cancer-therapy--a-review/anusree-s

    engineering journal, open access journal of chemistry, indexed journal
    Posted by at No comments:
    Labels:

    Ad