International Journal of Trend in Scientific Research and Development

Solubility are often defined because the amount of solute dissolved during a solvent at certain conditions to yield a single ¬phase system. Solubility of active pharmaceutical ingredients is taken into account the foremost parameter to urge the most desired drug concentration generally circulation so as to realize the specified therapeutic effect. Poor aqueous solubility considered the most problem occurs within the formulation progress of latest chemical entities additionally to the quality improvement solubility is that the main dispute for formulation scientists. The drug must appear as solution at the location of absorption so as to be absorbed. Many physical or chemical modification techniques are wont to improve the solubility of low aqueous soluble drugs, in addition to other techniques like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant and complexation. The selection of the solubility improvement methods depends on drug characteristics, location of absorption and therefore the features of the administered dosage form. 

by Utkarsha R. Gavhane | Trusha P. Shangrapawar | Ashok Bhosale "A Review: Solubility Enhancement and its Technique" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd42415.pdf 

Paper URL: https://www.ijtsrd.compharmacy/pharmaceutics/42415/a-review-solubility-enhancement-and-its-technique/utkarsha-r-gavhane

callforpaperarts, artsjournal, peerreviewedjournal 

A Microsponge Delivery System MDS is patented, highly cross linked, porous, polymeric microspheres that can entrap wide range of actives and then release them onto the skin over a time and in response to trigger. It is a unique technology for the controlled release of topical agents and consists of microporous beads, typically 10 25 microns in diameter, loaded with active agent. In this study, Ketoconazole microsponges were prepared by using quasi emulsion solvent diffusion method. The microsponges thus prepared, were evaluated for production yield, loading efficiency, particle size analysis, in vitro release study of microsponges, and stability. Hence, the present work concluded that MDS has a great potential in topical delivery of drugs like Ketoconazole, with added advantage of reduction in irritation profile due to the controlled release and possible enhancement in the activity due to amorphization of the drug. 

by Vilas S. Bhagat | Sanjay R. Arote "Formulation Development and In-Vitro Evaluation of Microsponge Drug Delivery System of Antifungal Drug" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3 , April 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd39870.pdf 

Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/39870/formulation-development-and-invitro-evaluation-of-microsponge-drug-delivery-system-of-antifungal-drug/vilas-s-bhagat

callforpaperbiologicalscience, biologicalsciencejournal

Objective Nanostructured lipid carrier NLC based topical gel of Piroxicam PXM was formulated with the aim of controlled release action and to reduce systemic side effect for the treatment of an arthritic condition. Methods NLCs developed using high pressure homogenization method and optimized using a 32 factorial design with response surface methodology using design expert software. NLCs were characterized for particle size, zeta potential analysis, drug entrapment efficiency, and in vitro drug release studies to select the optimized formulation. The NLCs were suitably gelled and evaluated with respect to homogeneity, pH, viscosity, gel strength, spread ability, rheological characteristics, drug content, in vitro diffusion, and stability study. Safety of the NLC based gel was assessed using primary skin irritation studies, and efficacy was confirmed using carrageen an induced rat paw edema model. Results NLCs formulation comprising 2 of lipid 60 40 and surfactant 1.50 was confirmed as an optimized batch having a particle size 138.2±3.60 nm with polydispersibility index value 0.344±0.034. The zeta potential value indicates good physical stability. Based on the results from the in vitro release study it was shown that the formed gels had the ability to extend release of PXM for 24 h and showing percentage drug release of 90.92 ±1.96 at the end of 24 h. Skin irritation studies revealed that the optimized gel formulation shows no erythema, edema, or ulceration. Conclusion The overall results of the present study clearly indicated promising potentials of NLC based gel for delivering PXM topically over the conventional gel. 

by Dr. G. Jagadish | Dr. Rita Mourya | Dr. Amith Nayak "Piroxicam Nanostructured Lipid Carrier Drug Delivery System" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3 , April 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd39912.pdf 

Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/39912/piroxicam-nanostructured-lipid-carrier-drug-delivery-system/dr-g-jagadish

internationaljournalsinengineering, callforpaperengineering, ugcapprovedengineeringjournal 

Deaths that are caused due to coronary heart disease CHD is a major cause of deaths in most of the population. Even though the mortality rate has been reducing, dyslipidemia is the major known risk factor in pathogenesis of CHD. In this paper we review the role of dyslipidemia and lipid changes that occur in men and women at different stages. We discuss about dyslipidemia causes symptoms and treatments and all the other issues that arise due to dyslipidemia. We talk about different drugs that are used in treating dyslipidemia and their side effects. 

by Yong Yuan | Wen Chen | Lei Luo | Chen Xu "Dyslipidemia: Causes, Symptoms and Treatment" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38594.pdf 

Paper Url: https://www.ijtsrd.com/pharmacy/pharmaceutics/38594/dyslipidemia-causes-symptoms-and-treatment/yong-yuan

callforpapermedicalscience, medicalsciencejournal

Size reduction is one of most fundamental unit operation which is of prime importance in pharmacy. It helps in improving stability and bioavailability, reducing toxicity, enhancing release and providing better formulation opportunities for drug. In the recent trends, the drugs in nanometer size range have found to increase the performance in variety of dosage forms. The word 'nano’ is a Latin word, which means'dwarf’. Nano size refers to 10 9 of a particular unit thus nanometer is 10 9 of a meter. Nanotechnology is the science that deals with the processes that occurs at molecular level and of nanolength scale size. Nanotechnology has shown tremendous progress in many fields but in pharmaceutical fields are yet to be explored, although, it has powerful impact in various medical fields such as biophysics, molecular biology, bioengineering, cardiology, oncology, ophthalmology, endocrinology immunology etc. Nanotechnology provides intelligent system, devices and materials for better pharmaceutical applications. The current status of nanotechnology in pharmaceutical field includes development of Nano medicine, tissue engineering, nano robots, biosensors, biomarkers etc. Pharmaceutical Nanotechnology provides opportunities to improve materials, medical devices and help to develop new technology where existing and more conventional technologies may be reaching their limits. Thus in the coming years advancements in this field will led to the improved form of drug delivery as well as other prospects of medicine and pharmacy.

by Mr. Rajesh Dumpala | Mr. Chirag Patil "Current Trends of “Nanotechnology” in Pharmaceutical" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd38414.pdf 

Paper Url: https://www.ijtsrd.com/pharmacy/pharmaceutics/38414/current-trends-of-“nanotechnology”-in-pharmaceutical/mr-rajesh-dumpala

callforpaperchemistry, chemistryjournal, openaccessjournalofchemistry