International Journal of Trend in Scientific Research and Development

The Pharmaceutical Quality By Design QBD is a systematic approach to the development that starts with the predetermined objectives and is based on the process of understanding process processes and process control, sound science and quality risk management. Quality Design QBD has been created to increase the assured of providing safe, effective medicines to customers and promised to make significant improvements in product quality performance. 

Water pollution is one of the major global environmental problems. It is an acute problem almost in all major rivers and water reservoirs in India. Water pollution is increasing and becoming severe day by day and posing a great risk to human health and other living organisms. There is growing concern on the deterioration of ground water quality due to geogenic and anthropogenic activities. Present investigation aims at insight about the level of contaminants of surface water, groundwater and sediment analysis of selected rivers of Krishna River located in Mahuli and Urmodi river located in Nagthane, Satara district. An attempt has been made to assess the water quality, sediment analysis of the samples. Dissolved oxygen content of the water samples was observed quite well in limits such as in Krishna river Mahuli DO was 27.68mg L and in Urmodi river Nagthane was13.68mg .In the present study, COD value was observed by 720mg l at surface water of Krishna River Mahuliand 1320 mg l at surface water sample of Urmodi river Nagthane. As expected groundwater samples showed values of hardness within a limit. There is an urgent need for more representative samples to be used to go beyond preliminary assessment as reported in the present study for making appropriate recommendations. 

The synthesis of Schiff base From Aromatic Amine And Aromatic P Nitro benzaldehyde was performed by a novel method of stirring followed by the addition of p nitro benzaldehydeandm nitro aniline 0.02M . Characterization of the synthesized compounds, determination of purity and identity of the compounds using following spectroscopic and chromatographic techniques Solubility, Thin Layer Chromatographic studies, Ultra Violet studied rotational and vibrational studies FT IR studies. The compounds were investigated for their Antimicrobial activity by cup plate method. Compound1 nitro 4 1 imino,4 nitrophenyl benzene was found to be the most active according to pharmacological evaluation exhibited antimicrobial.