International Journal of Trend in Scientific Research and Development

Multiple sclerosis is a chronic inflammatory neurodegenerative disorder which directly affects Central Nervous System CNS . People with MS suffer with an episodic reversible memory loss during the initial stages and later it leads to the neurological deterioration. Number of research and studies has been done on the natural compounds and phytochemical compounds in order to develop the particular drug for the treatment of MS in vivo andin vitro. The present study focuses on the inhibitory effect of Rosmarinic acid against the effect of CD2 Associated protein with the help of Molecular Docking. Molecular Docking basically screens the ligand and the target protein and shows the interaction between them on the basis of the minimum binding affinities and drug likeliness properties. In our research, docking was performed between CD2 Associated protein and selected ligands with the help of docking software. Ligands were selected on the basis of their minimum Binding affinities and finally by their drug likeliness properties. Rosmarinic acid BA 5.6 was the resultant ligand of our recent study. It showed the perfect interaction with CD2 Associated protein. Therefore, we may conclude that Rosmarinic acid may act as a compound which may be used as a drug for the treatment of multiple sclerosis fromfurther in vitro and in vivostudies in future. 

by Jitin Kumar | Tejaswee Anand | Ritika Sharma | Noopur Khare | Abhimanyu Kumar Jha | Yamini Dixit "A Possible Role of Rosmarinic Acid against CD2-Associated Protein for the Treatment of Multiple Sclerosis through in Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd44979.pdf 

Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/44979/a-possible-role-of-rosmarinic-acid-against-cd2associated-protein-for-the-treatment-of-multiple-sclerosis-through-in-silico-approach/jitin-kumar

openaccessjournalofengineering, engineeringjournal, paperpublicationforengineering

In the present study, two plant species of the family Asteraceae were selected for an evaluation of their phytochemical screening, antioxidant and anti inflammatory properties. Phytochemical alkaloids, phenols, protein, flavonoids, quinines, tannins, and terpenoids are present in the aqua methanol and aqua acetone extract s of Cirsium arvense L Cronquist and Erigeron bonariensis. The selected plant species exhibit anti inflammatory properties in both solvents. The enzymatic antioxidant property of selected plant species was evaluated by superoxide dismutase SOD , peroxidase POD , and catalase CAT . E. bonariensis shows 20.05±0.02 superoxide dismutase activity which is moreover equal to C. arvense 19.47±0.31 . POD and CAT activities of C. arvense 109.35±0.69 and 41.48±0.13 and E. bonariensis 105.91±1.53 and 39.63±0.035 respectively, the POD activity of C. arvense is slightly higher than E. bonariensis but CAT activity again higher in E. bonariensis same as SOD. 

Deepti Rawat | P. B. Rao "Qualitative Phytochemical Screening and In-Vitro Assessment of Antioxidant and Anti-Inflammatory Potential of Aqua Methanol and Aqua Acetone Extract of Cirsium Arvense and Erigeron Bonariensis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd43934.pdf 

Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43934/qualitative-phytochemical-screening-and-invitro-assessment-of-antioxidant-and-antiinflammatory-potential-of-aqua-methanol-and-aqua-acetone-extract-of-cirsium-arvense-and-erigeron-bonariensis/deepti-rawat

peerreviewedjournals, reviewpapers, callforpaperhealthscience

Diabetes mellitus is an autoimmune disorder which causes impairment in the insulin secretion or resistance. The prevalence of Diabetes is increasing day by day worldwide, also this metabolic disorder diseases is associated with high risk of cardiac problem, obesity and many other diseases. Although, there are different medications and treatments are available but still they have proven to be ineffective and associated with severe adverse effects for long term. Therapeutic compounds based on herbal phytochemicals are considered as the most prominent for the treatments. The computational study helps in finding the structural basis analysis of the compounds by rapid screening tools with rational drug designing. This study aims to identify the natural inhibitor of Rad GTP binding protein to treat Diabetes dysfunctionality.Therefore, by searching the natural compounds against Rad GTPase binding protein with 2DPX structure, all the important data was retrieved by using online webservers followed by computing docking score in AutoDock Vina. Out of three selected compounds, Gedunin was used to dock with the protein 2DAX protein structure, as it follows the both criteria for proceeding further, one is to follow lowest binding criteria then ADME Absorption, Distribution, Metabolism and excretion . The docking score of Gedunin compound shows that, this bioactive agent can go against the Diabetes mellitus and inhibits the expression of Rad GTPase. By result Gedunin has shown its therapeutic role with 7.9 kcal mol value. It has been concluded that in future Gedunin may act as a novel drug target. 

Chanchal Prajapati | Varsha Prajapati | Mishka Tyagi | Noopur Khare | Abhimanyu Kumar Jha "Study of the Effect of Gedunin against Protein-GTP-Binding Protein RAD to Treat Diabetes: An In-Silico Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd43888.pdf 

Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43888/study-of-the-effect-of-gedunin-against-proteingtpbinding-protein-rad-to-treat-diabetes-an-insilico-approach/chanchal-prajapati

ugcapprovedjournalswithlowpublicationfees, conferenceissuepublication

Diabetes is one of the major causes of death in the world, affecting around 422 million people or 8.5 percent of the worlds population . Diabetes mellitus, or diabetes, is a disease that causes excessive blood sugar levels. Diabetes mellitus is a condition where a person does not produce enough insulin or does not link directly to insulin, and resulting in excessively high blood sugar glucose levels. Diabetes is classified into several types Prediabetes, Type 1 diabetes, Type 2 diabetes and gestational diabetes. In diabetes research, numerous bioinformatics technologies are used. The current research was carried to study the effect of naturally occurring compounds against Aquaporin 2 as the target protein molecule with the help of molecular docking for diabetes diagnosis. AQP2 is found in the apical cell of the main ducts of the kidney and in the vesicles intracellular in the cells. Docking experiment were performed out by using aquaporin 2 4nef . The technique of molecular docking was utilized to investigate the potential of naturally occurring compounds such as aglycone, gedunin, and harman with the target protein Aquaporin 2 4nef . In diabetes, gedunin may function as a therapeutic drug against the disease causing protein Aquaporin 2 4nef . Further research and then certain clinical and pre clinical studies may be allowed to discover drugs that can be used to treat diabetes. 

Ayushi Chaudhary | Noopur Khare | Tripti Bhatnagar | Abhimanyu Kumar Jha "The Role of Gedunin Against Aquaporin 2 for the Possible Treatment of Diabetes: An In Silico Study" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5 , August 2021, 

URL: https://www.ijtsrd.com/papers/ijtsrd43788.

pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/43788/the-role-of-gedunin-against-aquaporin-2-for-the-possible-treatment-of-diabetes-an-in-silico-study/ayushi-chaudhary

callforpapermathematics, mathematicsjournal, ugcapprovedjournalsinmathemetics

Breast cancer is the most frequently diagnosed cancer it has been treated for a long time with hormonal, medical assistance, surgery, chemotherapy, and irradiation. Natural compounds obtained for living organisms facilitate caspase mediated cell death and inhibit metastasis, so cancer growth is often prevented with greater efficacy. These compounds are often found to slow the progression of breast cancer. They improved patient survival rates and minimized the number of deaths caused by breast cancer. Apoptosis is defined as the death of cells that occurs as a natural and controlled part of an organisms growth or development. The production of membrane enclosed apoptotic bodies with well preserved organelles, as well as rapid cell condensation and budding. Within the process, there are certain morphological changes. The most important indicator of apoptosis induction is the presence of Cytotoxic anticancer agent. Some plant and natural chemicals promote apoptosis, which obstruct cancer cells through a variety of processes. 

by Komal Kaushik | Gunjan Choudhary | Akanksha | Vandana | Shweta Tyagi | Abhimanyu Kumar Jha "Potential of Natural Compounds in Treating Breast Cancer" 

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, 

URL: https://www.ijtsrd.compapers/ijtsrd42410.pdf 

Paper URL: https://www.ijtsrd.combiological-science/biotechnology/42410/potential-of-natural-compounds-in-treating-breast-cancer/komal-kaushik

callforpapertechnology, technologyjournal